There were 16 979 total posts, 8 in November and December 2010, 2478 in 2017, 3375 in 2018, and 908 in January and February 2019 ( Figure).

All analyses adhered to Reddit’s terms and conditions, relied on existing public data with nonidentifiable participants, and were exempted by the University of California, San Diego human research protections program. R statistical software version 3.5.3 (R Foundation) was used to compute the percent of posts (with 95% CIs) that requested a primary or second-opinion crowd-diagnosis, contained an image of the physical signs, or received a reply, and the time to first reply from the random sample. Three authors (A.L.N., E.C.L., and J.W.A.) independently coded whether each post requested a crowd-diagnosis and if so, whether that request was made to obtain a second opinion after seeing a health care professional, using directed content analysis. To quantify the extent to which crowd-diagnosis occurred on r/STD, we drew a random sample of 500 posts. r/STD metadata, including the number of posts and time stamps, were described for the full sample. 6 We first obtained all posts from inception of the subreddit in November 2010 through February 2019. Reddit, a social media website with 330 million monthly active users that hosts more than 232 health forums, 5 includes a large subreddit (r/STD) that allows users to publicly share “stories, concerns and questions” about “anything and everything STD -related.” We selected r/STD because it focuses exclusively on a health topic of substantial public health concern.

Shared Decision Making and Communication.

Scientific Discovery and the Future of Medicine.

Health Care Economics, Insurance, Payment.

Clinical Implications of Basic Neuroscience.

Challenges in Clinical Electrocardiography.

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